{"id":30100,"date":"2022-05-07T18:15:47","date_gmt":"2022-05-07T18:15:47","guid":{"rendered":"https:\/\/www.ivo.es\/systemic-treatments\/drugs-directed-against-molecular-targets\/"},"modified":"2022-05-31T08:55:20","modified_gmt":"2022-05-31T08:55:20","slug":"drugs-directed-against-molecular-targets","status":"publish","type":"page","link":"https:\/\/www.ivo.es\/en\/systemic-treatments\/drugs-directed-against-molecular-targets\/","title":{"rendered":"Drugs directed against molecular targets"},"content":{"rendered":"\t\t
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\n\t\t\t\t\t\t\t\t\tA\u00a0therapeutic target<\/strong>\u00a0is a substance located in any part of a cell capable of recognizing a drug and producing cellular response.\r\n\r\nThese drugs are designed to\u00a0act against specific molecules (target molecules)<\/strong>\u00a0required for tumour development by blocking or deactivating them, thus producing cellular death or impeding cell growth.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Levels of action<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tThe most common drugs directed against molecular targets currently used can work on several levels. These are examples of drugs directed against molecular targets: trastuzumab, lapatinib, cetuximab, panitumumab,imatinib, erlotinib, gefitinib, sunitinib, bevacizumab, everolimus, temsirolimus, bortezomid, etc..\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Cell membrane<\/h3> <\/div>\n
On the extracellular level, monoclonal antibodies which act on receptors and on the intracellular level, a drug that inhibits an enzyme called tyrosine kinases.<\/div> <\/div>\n <\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Intracellular levels<\/h3> <\/div>\n
With cell cycle inhibitors, proteasome inhibitors and cell-signaling pathways<\/div> <\/div>\n <\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Extracellular level<\/h3> <\/div>\n
With antiangiogenic drugs, which block the formation of new blood vessels and with drugs that act on proteins of the extracellular matrix<\/div> <\/div>\n <\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Immune systems<\/h3> <\/div>\n
Through vaccines<\/div> <\/div>\n <\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\"\"<\/figure>

Medical Services<\/h3>

The IVO's specialisation in oncology allows for a service structure organised by care areas classified according to the type of tumour<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\"\"<\/figure>

Tumour Committees<\/h3>

The committees are the ultimate expression of multidisciplinary medicine. They are made up of expert physicians from the main oncological specialities.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Admission and Information<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Any citizen with cancer or a certified oncological suspicion can apply to be a patient at the Instituto Valenciano de Oncolog\u00eda.<\/p>

As it has an agreement with the Public Health System, patients do not have to assume any costs for their treatment.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

A\u00a0therapeutic target\u00a0is a substance located in any part of a cell capable of recognizing a drug and producing cellular response. These drugs are designed to\u00a0act against specific molecules (target molecules)\u00a0required for tumour development by blocking or deactivating them, thus producing cellular death or impeding cell growth. Levels of action The most common drugs directed against […]<\/p>\n","protected":false},"author":1,"featured_media":26775,"parent":30088,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"footnotes":""},"class_list":["post-30100","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.ivo.es\/en\/wp-json\/wp\/v2\/pages\/30100","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ivo.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ivo.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ivo.es\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ivo.es\/en\/wp-json\/wp\/v2\/comments?post=30100"}],"version-history":[{"count":1,"href":"https:\/\/www.ivo.es\/en\/wp-json\/wp\/v2\/pages\/30100\/revisions"}],"predecessor-version":[{"id":30101,"href":"https:\/\/www.ivo.es\/en\/wp-json\/wp\/v2\/pages\/30100\/revisions\/30101"}],"up":[{"embeddable":true,"href":"https:\/\/www.ivo.es\/en\/wp-json\/wp\/v2\/pages\/30088"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ivo.es\/en\/wp-json\/wp\/v2\/media\/26775"}],"wp:attachment":[{"href":"https:\/\/www.ivo.es\/en\/wp-json\/wp\/v2\/media?parent=30100"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}